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10 more recently, a positive association between serum digoxin concentrations and mortality was again demonstrated in patients with end-stage renal failure ehr 1.

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if the patient s clinical response necessitates a change from the calculated loading dose of digoxin, then calculation of the maintenance dose should be based upon the amount actually given as the loading dose see table 1 and 2 .

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where possible, digoxin should be used with a diuretic and an angiotensin-converting enzymeinhibitor, but an optimal order for starting these three drugs cannot be specified.

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phentermine; topiramate moderate serum digoxin auc was decreased by 12 when coadministered with topiramate.

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